- Open to participants with newly diagnosed DMG between 2 and 39 years old who have not received any prior tumor-directed therapy for their DMG.
- Newly diagnosed or recurrent DMG patients who are eligible for a VAD or newly diagnosed or recurrent DMG patients with preexisting reservoir or device/shunt or VAD regardless of where they are in the disease continuum.
Detailed eligibility reviewed when participant contacts the study team.
This clinical trial is for participants with diffuse midline glioma (DMG).
The purpose of this study is to better understand if cerebrospinal fluid (CSF) and blood obtained as a liquid biopsy correlates with disease status in patients with diffuse malignant gliomas. This study is being done because CSF and blood can provide critical information about the status of the diffuse midline glioma. Through the CSF and blood samples, researchers can detect molecules called cell-free DNA (cfDNA). These molecules can shed off from the tumor and are circulated in the CSF and blood. By analyzing cfDNA, researchers can have a better understanding on the status of the tumor.
This study will include the collection of CSF, blood samples, and implementation of the ventricular access device (VAD) for participants who have not already had a VAD implanted as part of their clinical care.
Participation in this research will last about 2 years including follow-up.