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Adherus Dural Sealant in Endoscopic Skull Base Surgery: Safety, Imaging Characteristics, and Sinonasal Quality of Life.

TitleAdherus Dural Sealant in Endoscopic Skull Base Surgery: Safety, Imaging Characteristics, and Sinonasal Quality of Life.
Publication TypeJournal Article
Year of Publication2020
AuthorsSoneru CP, Riley CA, Minkowitz S, Tabaee A, Anand VK, Schwartz TH
JournalJ Neurol Surg B Skull Base
Volume81
Issue6
Pagination659-663
Date Published2020 Dec
ISSN2193-6331
Abstract

 This study was aimed to compare the safety profiles, magnetic resonance imaging (MRI) findings, and sinonasal outcome test (SNOT-22) scores of Adherus dural sealant, a novel tissue glue designed for skull base surgery.  Present study is a prospective case series.  The research work took place at a tertiary-care academic medical center.  Consecutive series of 26 patients undergoing endoscopic skull base surgery (ESBS) with Adherus was compared with a control group of 24 patients matched for tumor type and size with DuraSeal as a sealant.  Postoperative complication rates, imaging characteristics, and postoperative SNOT-22 scores were measured and compared.  No postoperative cerebrospinal fluid (CSF) leaks, intracranial hemorrhages, or mucoceles were observed in either cohort. Adherus was more likely to be identifiable on immediate postoperative MRI (50 vs. 20.8%,  = 0.032). In patients in whom a nasoseptal flap was utilized, the flap was opposed to the skull base in all cases regardless of sealant selected. Postoperative SNOT-22 total (17.25 [±10.81] vs. 14.85 [±14.22],  = 0.609) and subdomain scores were similar between the two groups.  Adherus dural sealant appears to be a safe alternative to Duraseal in ESBS with comparable quality of life outcomes and imaging findings. These preliminary results are promising but should be examined in a larger population with long-term follow-up.

DOI10.1055/s-0039-1694048
Alternate JournalJ Neurol Surg B Skull Base
PubMed ID33381370
PubMed Central IDPMC7755501