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The Impact of Age on Long-Term Quality of Life After Endonasal Endoscopic Resection of Skull Base Meningiomas.

TitleThe Impact of Age on Long-Term Quality of Life After Endonasal Endoscopic Resection of Skull Base Meningiomas.
Publication TypeJournal Article
Year of Publication2016
AuthorsJones SH, Iannone AF, Patel KS, Anchouche K, Raza SM, Anand VK, Schwartz TH
JournalNeurosurgery
Volume79
Issue5
Pagination736-745
Date Published2016 Nov
ISSN1524-4040
KeywordsAdult, Age Factors, Aged, Aged, 80 and over, Databases, Factual, Female, Humans, Male, Meningeal Neoplasms, Meningioma, Middle Aged, Nasal Cavity, Natural Orifice Endoscopic Surgery, Neuroendoscopy, Postoperative Period, Quality of Life, Skull Base, Surveys and Questionnaires, Treatment Outcome, Young Adult
Abstract

BACKGROUND: Midline ventral skull base meningiomas may be amenable to an endonasal endoscopic approach, which has theoretical advantages and may help preserve quality of life (QOL) when compared with transcranial approaches.

OBJECTIVE: To investigate the effect of age on QOL following endonasal endoscopic surgery, given the documented impact of age on QOL outcomes following transcranial resection of midline ventral skull base meningiomas.

METHODS: We reviewed a prospectively acquired database of endonasal endoscopic surgery for meningiomas. Inclusion criteria included patients who had completed long-term postoperative (≥6 months follow-up) QOL questionnaires (Anterior Skull Base Questionnaire [ASBQ] and Sino-Nasal Outcome Test [SNOT-22]). Postoperative QOL scores were also compared with preoperative QOL in a patient subset.

RESULTS: Long-term QOL data were available in 34 patients. Average postoperative ASBQ and SNOT-22 scores were 3.39 and 23.0, respectively. Better QOL was statistically associated with age <55 (P = .02). In a subset of patients, preoperative and postoperative ASBQ and SNOT-22 scores were compared. Only SNOT-22 scores significantly increased from 15.9 + 20.8 to 25.9 + 19.5 (P = .04).

CONCLUSION: We report the first study specifically evaluating long-term QOL after endonasal endoscopic resection of skull base meningiomas. QOL was decreased postoperatively in patients aged ≥55.

ABBREVIATIONS: ASBQ, Anterior Skull Base QuestionnaireGTR, gross total resectionQOL, quality of lifeSNOT-22, 22-item Sino-Nasal Outcome Test.

DOI10.1227/NEU.0000000000001360
Alternate JournalNeurosurgery
PubMed ID27465844