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Intraoperative brachytherapy for resected brain metastases.

TitleIntraoperative brachytherapy for resected brain metastases.
Publication TypeJournal Article
Year of Publication2019
AuthorsMahase SS, Navrazhina K, Schwartz TH, Parashar B, A Wernicke G
JournalBrachytherapy
Volume18
Issue3
Pagination258-270
Date Published2019 May - Jun
ISSN1873-1449
KeywordsBrachytherapy, Brain Neoplasms, Cesium Radioisotopes, Humans, Intraoperative Period, Iodine Radioisotopes, Postoperative Period, Radiosurgery, Radiotherapy, Adjuvant, Treatment Outcome
Abstract

Brain metastases are the most common intracranial malignancies in adults. Surgical resection is the preferred treatment approach when a pathological diagnosis is required, for symptomatic patients who are refractory to steroids, and to decompress lesions causing mass effect. Radiotherapy is administered to improve local control rates after surgical resection. After a brief review of the literature describing the treatment of brain metastases using whole-brain radiotherapy, postoperative stereotactic radiosurgery, preoperative radiosurgery, and brachytherapy, we compare patient-related, technical, practical, and radiobiological considerations of each technique. Finally, we focus our discussion on intraoperative brachytherapy, with an emphasis on the technical aspects, benefits, efficacy, and outcomes of studies utilizing permanent Cs-131 implants.

DOI10.1016/j.brachy.2019.01.011
Alternate JournalBrachytherapy
PubMed ID30850332