Intraoperative brachytherapy for resected brain metastases.

TitleIntraoperative brachytherapy for resected brain metastases.
Publication TypeJournal Article
Year of Publication2019
AuthorsMahase SS, Navrazhina K, Schwartz TH, Parashar B, A Wernicke G
Date Published2019 May - Jun
KeywordsBrachytherapy, Brain Neoplasms, Cesium Radioisotopes, Humans, Intraoperative Period, Iodine Radioisotopes, Postoperative Period, Radiosurgery, Radiotherapy, Adjuvant, Treatment Outcome

Brain metastases are the most common intracranial malignancies in adults. Surgical resection is the preferred treatment approach when a pathological diagnosis is required, for symptomatic patients who are refractory to steroids, and to decompress lesions causing mass effect. Radiotherapy is administered to improve local control rates after surgical resection. After a brief review of the literature describing the treatment of brain metastases using whole-brain radiotherapy, postoperative stereotactic radiosurgery, preoperative radiosurgery, and brachytherapy, we compare patient-related, technical, practical, and radiobiological considerations of each technique. Finally, we focus our discussion on intraoperative brachytherapy, with an emphasis on the technical aspects, benefits, efficacy, and outcomes of studies utilizing permanent Cs-131 implants.

Alternate JournalBrachytherapy
PubMed ID30850332