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Localization in epilepsy.

TitleLocalization in epilepsy.
Publication TypeJournal Article
Year of Publication2009
AuthorsPlacantonakis DG, Schwartz TH
JournalNeurol Clin
Volume27
Issue4
Pagination1015-1030
Date Published2009 Nov
ISSN1557-9875
KeywordsBrain, Electroencephalography, Epilepsy, Humans, Magnetic Resonance Imaging, Magnetoencephalography, Positron-Emission Tomography, Radiography, Tomography, Emission-Computed, Single-Photon
Abstract

Pharmacologic therapy represents the first line of treatment of epilepsy and is effective in most patients. However, about 20% to 30% of cases develop intractable seizures that cannot be controlled by medication alone. In such cases, surgical intervention is considered for therapeutic, often curative purposes. Dynamic spatiotemporal variability in the epileptic focus renders seizure localization a challenge to the clinician. Many diagnostic modalities have been developed to identify different aspects of the epileptic focus. Older techniques are being increasingly supplemented by a variety of anatomic and functional imaging modalities that can help clarify discrepancies. Invasive electroencephalography remains the gold standard for identifying epileptic foci and guiding the surgeon to successful resections.

DOI10.1016/j.ncl.2009.08.004
Alternate JournalNeurol Clin
PubMed ID19853221