Title | Malignant Transformation in Glioma Steered by an Angiogenic Switch: Defining a Role for Bone Marrow-Derived Cells. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Xu R, Pisapia D, Greenfield JP |
Journal | Cureus |
Volume | 8 |
Issue | 1 |
Pagination | e471 |
Date Published | 2016 Jan 27 |
ISSN | 2168-8184 |
Abstract | Low-grade gliomas, such as pilocytic astrocytoma and subependymoma, are often characterized as benign tumors due to their relative circumscription radiologically and typically non-aggressive biologic behavior. In contrast, low-grades that are by their nature diffusely infiltrative, such as diffuse astrocytomas and oligodendrogliomas, have the potential to transform into malignant high-grade counterparts and, given sufficient time, invariably do so. These high-grade gliomas carry very poor prognoses and are largely incurable, warranting a closer look at what causes this adverse transition. A key characteristic that distinguishes low- and high-grade gliomas is neovascularization: it is absent in low-grade gliomas, but prolific in high-grade gliomas, providing the tumor with ample blood supply for exponential growth. It has been well described in the literature that bone marrow-derived cells (BMDCs) may contribute to the angiogenic switch that is responsible for malignant transformation of low-grade gliomas. In this review, we will summarize the current literature on BMDCs and their known contribution to angiogenesis-associated tumor growth in gliomas. |
DOI | 10.7759/cureus.471 |
Alternate Journal | Cureus |
PubMed ID | 26973806 |
PubMed Central ID | PMC4772998 |