|Neuroanatomic Correlates for the Neuropsychological Manifestations of Chiari Malformation Type I.
|Year of Publication
|Steinberg SN, Greenfield JP, Perrine K
|Adolescent, Adult, Arnold-Chiari Malformation, Bone Screws, Cadaver, Child, Child, Preschool, Feasibility Studies, Female, Fracture Fixation, Internal, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuronavigation, Neurosurgical Procedures, Skull, Spinal Fusion, Tomography, X-Ray Computed, Treatment Outcome, Young Adult
Chiari malformation comprises a spectrum of congenital malformations characterized by a herniation of the cerebellar tonsils below the foramen magnum. Chiari malformation type I (CM-I) is the most prevalent subtype seen in clinical practice. This condition variably compresses the cerebellum and medulla-spinal cord junction secondary to malformation of the posterior fossa. Most neurologists and neurosurgeons recognize the sensorimotor and lower brainstem manifestations that result in the clinical picture of CM-I. The effects of CM-I on cognitive functioning, however, and their impact on neuropsychological performance are poorly understood, despite having long been recognized. This article reviews neuropsychological deficits demonstrated by individuals with CM-I, and explores cerebellocortical neuroanatomic pathways to provide possible rationale for the neurocognitive impairments present in affected individuals.