Neuroanatomic Correlates for the Neuropsychological Manifestations of Chiari Malformation Type I.

TitleNeuroanatomic Correlates for the Neuropsychological Manifestations of Chiari Malformation Type I.
Publication TypeJournal Article
Year of Publication2020
AuthorsSteinberg SN, Greenfield JP, Perrine K
JournalWorld Neurosurg
Date Published2020 Apr
KeywordsAdolescent, Adult, Arnold-Chiari Malformation, Bone Screws, Cadaver, Child, Child, Preschool, Feasibility Studies, Female, Fracture Fixation, Internal, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuronavigation, Neurosurgical Procedures, Skull, Spinal Fusion, Tomography, X-Ray Computed, Treatment Outcome, Young Adult

Chiari malformation comprises a spectrum of congenital malformations characterized by a herniation of the cerebellar tonsils below the foramen magnum. Chiari malformation type I (CM-I) is the most prevalent subtype seen in clinical practice. This condition variably compresses the cerebellum and medulla-spinal cord junction secondary to malformation of the posterior fossa. Most neurologists and neurosurgeons recognize the sensorimotor and lower brainstem manifestations that result in the clinical picture of CM-I. The effects of CM-I on cognitive functioning, however, and their impact on neuropsychological performance are poorly understood, despite having long been recognized. This article reviews neuropsychological deficits demonstrated by individuals with CM-I, and explores cerebellocortical neuroanatomic pathways to provide possible rationale for the neurocognitive impairments present in affected individuals.

Alternate JournalWorld Neurosurg
PubMed ID32204298