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Pediatric Gliomatosis Cerebri: A Review of 15 Years.

TitlePediatric Gliomatosis Cerebri: A Review of 15 Years.
Publication TypeJournal Article
Year of Publication2016
AuthorsGeorge E, Settler A, Connors S, Greenfield JP
JournalJ Child Neurol
Volume31
Issue3
Pagination378-87
Date Published2016 Mar
ISSN1708-8283
KeywordsAdolescent, Brain Neoplasms, Female, Humans, Male, Neoplasms, Neuroepithelial, Young Adult
Abstract

Gliomatosis cerebri is a rare glial tumor that carries a poor prognosis. Seen in both adults and children, gliomatosis cerebri appears to differ in these populations as with adult versus pediatric glioblastoma. We present 10 children who either presented to the Weill Cornell Medical College or enrolled in the institution's Gliomatosis Cerebri International Registry alongside a cohort of 89 pediatric patients reported in the literature between 2000 and 2014. Age ranged from 4 months to 21 years, with a male to female ratio of 1.71. Median overall survival for patients in the registry cohort was 17 months (n = 10) and for the historic cohort was 13 months (n = 52). Overall survival was analyzed for the combined cohort and was significantly longer when presenting at age ≥ 10 (20 vs 10 months), for boys (18 vs 11 months), and with low-grade pathology (26.5 vs 12 months) but did not vary significantly by treatment approach.

DOI10.1177/0883073815596612
Alternate JournalJ Child Neurol
PubMed ID26239491