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A Potential Role For Apparent Diffusion Coefficient in the Diagnosis of Trilateral Retinoblastoma.

TitleA Potential Role For Apparent Diffusion Coefficient in the Diagnosis of Trilateral Retinoblastoma.
Publication TypeJournal Article
Year of Publication2020
AuthorsSait SFarouk, Haque S, Karimi S, Rebeiz KJ, Francis JH, Marr BP, Abramson DH, Souweidane MM, Dunkel IJ
JournalJ Pediatr Hematol Oncol
Volume42
Issue3
Pagination238-243
Date Published2020 04
ISSN1536-3678
KeywordsChild, Preschool, Diffusion Magnetic Resonance Imaging, Female, Humans, Infant, Male, Neuroimaging, Retinal Neoplasms, Retinoblastoma, Retrospective Studies
Abstract

We attempted to investigate the potential role for apparent diffusion coefficient (ADC) to diagnose trilateral retinoblastoma (TRb) by retrospectively reviewing brain magnetic resonance images of retinoblastoma patients. Observations: The median ADC measured 620.95 for TRb (n=6) and 1238.5 for normal pineal gland in bilateral retinoblastoma (n=8). Monitoring ADC trends aided in establishing the appropriate diagnoses in 3 patients (2 TRb, 1 benign pineal cyst). Conclusions: Our results provide baseline reference data and describe the importance of downward trending ADC which should prompt consideration of TRb. Unchanged high/nonrestricted values (>1000) may distinguish those with benign pineal tissue and obviate invasive neurosurgical procedures.

DOI10.1097/MPH.0000000000001523
Alternate JournalJ Pediatr Hematol Oncol
PubMed ID31259824