| Title | A Potential Role For Apparent Diffusion Coefficient in the Diagnosis of Trilateral Retinoblastoma. |
| Publication Type | Journal Article |
| Year of Publication | 2020 |
| Authors | Sait SFarouk, Haque S, Karimi S, Rebeiz KJ, Francis JH, Marr BP, Abramson DH, Souweidane MM, Dunkel IJ |
| Journal | J Pediatr Hematol Oncol |
| Volume | 42 |
| Issue | 3 |
| Pagination | 238-243 |
| Date Published | 2020 04 |
| ISSN | 1536-3678 |
| Keywords | Child, Preschool, Diffusion Magnetic Resonance Imaging, Female, Humans, Infant, Male, Neuroimaging, Retinal Neoplasms, Retinoblastoma, Retrospective Studies |
| Abstract | We attempted to investigate the potential role for apparent diffusion coefficient (ADC) to diagnose trilateral retinoblastoma (TRb) by retrospectively reviewing brain magnetic resonance images of retinoblastoma patients. Observations: The median ADC measured 620.95 for TRb (n=6) and 1238.5 for normal pineal gland in bilateral retinoblastoma (n=8). Monitoring ADC trends aided in establishing the appropriate diagnoses in 3 patients (2 TRb, 1 benign pineal cyst). Conclusions: Our results provide baseline reference data and describe the importance of downward trending ADC which should prompt consideration of TRb. Unchanged high/nonrestricted values (>1000) may distinguish those with benign pineal tissue and obviate invasive neurosurgical procedures. |
| DOI | 10.1097/MPH.0000000000001523 |
| Alternate Journal | J Pediatr Hematol Oncol |
| PubMed ID | 31259824 |