Title | A Potential Role For Apparent Diffusion Coefficient in the Diagnosis of Trilateral Retinoblastoma. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Sait SFarouk, Haque S, Karimi S, Rebeiz KJ, Francis JH, Marr BP, Abramson DH, Souweidane MM, Dunkel IJ |
Journal | J Pediatr Hematol Oncol |
Volume | 42 |
Issue | 3 |
Pagination | 238-243 |
Date Published | 2020 04 |
ISSN | 1536-3678 |
Keywords | Child, Preschool, Diffusion Magnetic Resonance Imaging, Female, Humans, Infant, Male, Neuroimaging, Retinal Neoplasms, Retinoblastoma, Retrospective Studies |
Abstract | We attempted to investigate the potential role for apparent diffusion coefficient (ADC) to diagnose trilateral retinoblastoma (TRb) by retrospectively reviewing brain magnetic resonance images of retinoblastoma patients. Observations: The median ADC measured 620.95 for TRb (n=6) and 1238.5 for normal pineal gland in bilateral retinoblastoma (n=8). Monitoring ADC trends aided in establishing the appropriate diagnoses in 3 patients (2 TRb, 1 benign pineal cyst). Conclusions: Our results provide baseline reference data and describe the importance of downward trending ADC which should prompt consideration of TRb. Unchanged high/nonrestricted values (>1000) may distinguish those with benign pineal tissue and obviate invasive neurosurgical procedures. |
DOI | 10.1097/MPH.0000000000001523 |
Alternate Journal | J Pediatr Hematol Oncol |
PubMed ID | 31259824 |