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Prognosis Factor in Oculomotor Schwannoma: A Case of Endoscopic Endonasal Approach and Systematic Review of the Literature.

TitlePrognosis Factor in Oculomotor Schwannoma: A Case of Endoscopic Endonasal Approach and Systematic Review of the Literature.
Publication TypeJournal Article
Year of Publication2019
AuthorsAsri ACherif El, Arnaout MM, Gerges MM, Gazzaz M, Mostarchid BEl, Schwartz TH
JournalWorld Neurosurg
Volume129
Pagination72-80
Date Published2019 Sep
ISSN1878-8769
KeywordsAdolescent, Adult, Aged, Child, Child, Preschool, Cranial Nerve Neoplasms, Female, Humans, Infant, Male, Middle Aged, Natural Orifice Endoscopic Surgery, Neurilemmoma, Neuroendoscopy, Neurosurgical Procedures, Oculomotor Nerve Diseases, Treatment Outcome
Abstract

BACKGROUND: We report the first case of oculomotor nerve (ON) schwannoma treatment through an endonasal endoscopic approach. We also review the literature to determine prognosis factors of ON function after treatment.

METHODS: A complete MEDLINE search was undertaken for all articles reporting data for oculomotor schwannoma. We divided the patient population into 2 groups; Group I: patients who conserved or recovered good ON function and Group II: patients with either new, worsening, or unchanged third-nerve palsy at the last available follow-up. We conducted a comparative statistical analysis of data between the 2 groups.

RESULTS: We identified 55 reported cases of ON schwannoma, all of whom were treated with open transcranial surgery, stereotactic radiosurgery, or observation. There were 22 patients in group I and 33 in group II. At admission, 29 patients had complete oculomotor nerve palsy (34.7% in group I and 67.7% in group II; P = 0.02). Surgical treatment was performed in 36 cases. Radiosurgery was performed in 3 cases. Among patients with good preoperative ON function, 34.6% worsened at last follow-up (26.6% after surgery and 50% with observation; P = 0.03). In total, 31% of patients with total or near-total palsy at admission had an improvement of their ON function (all after surgical resection; P = 0.05).

CONCLUSIONS: ON function at admission and surgical resection of schwannoma appears to be a predictive factor of favorable prognosis regardless of location and tumor size. The endonasal endoscopic approach can be used to biopsy tumors in cases in which open surgery is considered too risky, such as cavernous sinus schwannomas.

DOI10.1016/j.wneu.2019.05.170
Alternate JournalWorld Neurosurg
PubMed ID31150851