|Title||Quantitative evaluation of gadoxetate hepatocyte phase homogeneity: potential imaging markers for detection of early cirrhosis.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Boddu S, Brylka D, Dutruel SP, Spincemaille P, Prince MR|
|Date Published||2016 Sep-Oct|
|Keywords||Adult, Biomarkers, Biopsy, Case-Control Studies, Contrast Media, Female, Gadolinium DTPA, Humans, Liver, Liver Cirrhosis, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, ROC Curve, Young Adult|
OBJECTIVE: Does quantitative analysis of the gadoxetate hepatocyte phase homogeneity, measuring percent standard deviation of hepatocyte phase (SDHP) and liver-to-kidney enhancement ratio (LiKER) detect early hepatic fibrosis?
MATERIALS AND METHODS: Retrospective review of gadoxetate liver MRI plus biopsy-proven fibrosis within 6 months included 31 reversible hepatic fibrosis, 33 irreversible hepatic fibrosis, and 15 donors. Parenchymal and vascular SDHP and LiKER were measured on the 20-min hepatocyte phase using region of interest.
RESULTS: Parenchymal SDHP, vascular SDHP and LiKER measurements differentiate early hepatic fibrosis from controls (P<.01).
CONCLUSION: Quantitative analysis of gadoxetate hepatocyte phase homogeneity using SDHP and LiKER is a promising imaging biomarker for diagnosis of early liver fibrosis.
|Alternate Journal||Clin Imaging|