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Quantitative evaluation of gadoxetate hepatocyte phase homogeneity: potential imaging markers for detection of early cirrhosis.

TitleQuantitative evaluation of gadoxetate hepatocyte phase homogeneity: potential imaging markers for detection of early cirrhosis.
Publication TypeJournal Article
Year of Publication2016
AuthorsBoddu S, Brylka D, Dutruel SP, Spincemaille P, Prince MR
JournalClin Imaging
Volume40
Issue5
Pagination979-86
Date Published2016 Sep-Oct
ISSN1873-4499
KeywordsAdult, Biomarkers, Biopsy, Case-Control Studies, Contrast Media, Female, Gadolinium DTPA, Humans, Liver, Liver Cirrhosis, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, ROC Curve, Young Adult
Abstract

OBJECTIVE: Does quantitative analysis of the gadoxetate hepatocyte phase homogeneity, measuring percent standard deviation of hepatocyte phase (SDHP) and liver-to-kidney enhancement ratio (LiKER) detect early hepatic fibrosis?

MATERIALS AND METHODS: Retrospective review of gadoxetate liver MRI plus biopsy-proven fibrosis within 6 months included 31 reversible hepatic fibrosis, 33 irreversible hepatic fibrosis, and 15 donors. Parenchymal and vascular SDHP and LiKER were measured on the 20-min hepatocyte phase using region of interest.

RESULTS: Parenchymal SDHP, vascular SDHP and LiKER measurements differentiate early hepatic fibrosis from controls (P<.01).

CONCLUSION: Quantitative analysis of gadoxetate hepatocyte phase homogeneity using SDHP and LiKER is a promising imaging biomarker for diagnosis of early liver fibrosis.

DOI10.1016/j.clinimag.2016.05.004
Alternate JournalClin Imaging
PubMed ID27288740