| Title | Quantitative evaluation of gadoxetate hepatocyte phase homogeneity: potential imaging markers for detection of early cirrhosis. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Boddu S, Brylka D, Dutruel SP, Spincemaille P, Prince MR |
| Journal | Clin Imaging |
| Volume | 40 |
| Issue | 5 |
| Pagination | 979-86 |
| Date Published | 2016 Sep-Oct |
| ISSN | 1873-4499 |
| Keywords | Adult, Biomarkers, Biopsy, Case-Control Studies, Contrast Media, Female, Gadolinium DTPA, Humans, Liver, Liver Cirrhosis, Magnetic Resonance Imaging, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, ROC Curve, Young Adult |
| Abstract | OBJECTIVE: Does quantitative analysis of the gadoxetate hepatocyte phase homogeneity, measuring percent standard deviation of hepatocyte phase (SDHP) and liver-to-kidney enhancement ratio (LiKER) detect early hepatic fibrosis? MATERIALS AND METHODS: Retrospective review of gadoxetate liver MRI plus biopsy-proven fibrosis within 6 months included 31 reversible hepatic fibrosis, 33 irreversible hepatic fibrosis, and 15 donors. Parenchymal and vascular SDHP and LiKER were measured on the 20-min hepatocyte phase using region of interest. RESULTS: Parenchymal SDHP, vascular SDHP and LiKER measurements differentiate early hepatic fibrosis from controls (P<.01). CONCLUSION: Quantitative analysis of gadoxetate hepatocyte phase homogeneity using SDHP and LiKER is a promising imaging biomarker for diagnosis of early liver fibrosis. |
| DOI | 10.1016/j.clinimag.2016.05.004 |
| Alternate Journal | Clin Imaging |
| PubMed ID | 27288740 |