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Repeat surgery for recurrent low-grade gliomas should be standard of care.

TitleRepeat surgery for recurrent low-grade gliomas should be standard of care.
Publication TypeJournal Article
Year of Publication2016
AuthorsUppstrom TJ, Singh R, Hadjigeorgiou GF, Magge R, Ramakrishna R
JournalClin Neurol Neurosurg
Volume151
Pagination18-23
Date Published2016 Dec
ISSN1872-6968
KeywordsBrain Neoplasms, Glioma, Humans, Neoplasm Recurrence, Local, Neurosurgical Procedures, Reoperation, Standard of Care
Abstract

The importance of surgery and maximal extent of resection (EOR) is well established in primary low-grade glioma (LGG) management. However, the role of surgery in the management of recurrent LGG is less clear. A recent review on the management of recurrent LGG concluded there was insufficient evidence to recommend surgery. Here, we summarize the recent advances regarding the role of surgery, radiotherapy (RT) and chemotherapy in the management of recurrent LGG. There is increasing evidence to support maximal EOR for treating recurrent LGG, as it may improve progression free survival (PFS) after recurrence and overall survival (OS). Based on the studies presented in this review, we suggest that repeat surgery with maximal EOR should be standard of care for recurrent LGG treatment.

DOI10.1016/j.clineuro.2016.09.013
Alternate JournalClin Neurol Neurosurg
PubMed ID27736650