Title | Repeat surgery for recurrent low-grade gliomas should be standard of care. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Uppstrom TJ, Singh R, Hadjigeorgiou GF, Magge R, Ramakrishna R |
Journal | Clin Neurol Neurosurg |
Volume | 151 |
Pagination | 18-23 |
Date Published | 2016 Dec |
ISSN | 1872-6968 |
Keywords | Brain Neoplasms, Glioma, Humans, Neoplasm Recurrence, Local, Neurosurgical Procedures, Reoperation, Standard of Care |
Abstract | The importance of surgery and maximal extent of resection (EOR) is well established in primary low-grade glioma (LGG) management. However, the role of surgery in the management of recurrent LGG is less clear. A recent review on the management of recurrent LGG concluded there was insufficient evidence to recommend surgery. Here, we summarize the recent advances regarding the role of surgery, radiotherapy (RT) and chemotherapy in the management of recurrent LGG. There is increasing evidence to support maximal EOR for treating recurrent LGG, as it may improve progression free survival (PFS) after recurrence and overall survival (OS). Based on the studies presented in this review, we suggest that repeat surgery with maximal EOR should be standard of care for recurrent LGG treatment. |
DOI | 10.1016/j.clineuro.2016.09.013 |
Alternate Journal | Clin Neurol Neurosurg |
PubMed ID | 27736650 |