Somatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications.

TitleSomatostatin receptor-2 negative meningioma: pathologic correlation and imaging implications.
Publication TypeJournal Article
Year of Publication2020
AuthorsRoytman M, Pisapia DJ, Liechty B, Lin E, Skafida M, Magge RS, Osborne JR, Pannullo SC, Knisely JPS, Ramakrishna R, Ivanidze J
JournalClin Imaging
Date Published2020 Oct
KeywordsAged, Brain Neoplasms, Female, Humans, Indium Radioisotopes, Male, Meningeal Neoplasms, Meningioma, Middle Aged, Octreotide, Organometallic Compounds, Radionuclide Imaging, Radiopharmaceuticals, Receptors, Somatostatin, Tomography, X-Ray Computed

Meningiomas are the most common non-malignant primary intracranial tumors, accounting for nearly 40% of all primary brain tumors, usually expressing high levels of somatostatin receptors (SSTR), particularly SSTR2. Because Ga-DOTATATE targets SSTR2, it is increasingly used clinically for meningioma evaluation. While previous apparent lack of SSTR expression in meningiomas has been reported in isolated cases, these prior studies utilized Indium-111 (In) Octreotide, which is of lesser diagnostic accuracy compared to Ga-DOTATATE, as well as Technetium-99m (Tc)-DTPA scintigraphy, which necessitates an intact blood-tumor-permeability barrier. This paper presents a histopathologic proven atypical meningioma, WHO Grade II, with low level avidity on Ga-DOTATATE PET/MRI, subsequently proven to be SSTR2-negative by immunohistochemistry, with a review and discussion of the current literature and imaging implications.

Alternate JournalClin Imaging
PubMed ID32442855